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Journal of the American Academy of Dermatology
Volume 71, n° 1
pages 92-99 (juillet 2014)
Doi : 10.1016/j.jaad.2014.02.030
accepted : 25 February 2014
Original Articles

Incidence of bullous pemphigoid and mortality of patients with bullous pemphigoid in Olmsted County, Minnesota, 1960 through 2009
 

Katherine E. Brick, MD a, Chad H. Weaver, MD a, Christine M. Lohse, MS b, Mark R. Pittelkow, MD a, c, Julia S. Lehman, MD a, d, Michael J. Camilleri, MD a, d, Mustafa Al-Hashimi, MD a, Carilyn N. Wieland, MD a, d,
a Department of Dermatology, Mayo Clinic, Rochester, Minnesota 
b Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 
c Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 
d Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 

Reprint requests: Carilyn N. Wieland, MD, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Abstract
Background

Bullous pemphigoid (BP) is an autoimmune blistering disease that is associated with increased mortality.

Objective

We sought to determine the incidence and mortality of patients with BP.

Methods

A total of 87 residents of Olmsted County, Minnesota, were identified who had their first lifetime diagnosis of BP from January 1960 through December 2009. Incidence and mortality were compared with age- and sex-matched control patients from the same geographic area.

Results

The adjusted incidence of BP was 2.4 per 100,000 person-years (95% confidence interval, 1.9-2.9). Incidence of BP increased significantly with age (P < .001) and over time (P  = .034). Trend tests indicate increased diagnosis of localized disease (P  = .006) may be a contributing factor. Survival observed in the incident BP cohort was significantly poorer than expected (P < .001). Survival was not different among patients with multisite versus localized disease (P  = .90).

Limitations

Retrospective study design and study population from a small geographic area are limitations.

Conclusion

Incidence of BP in the United States is comparable with that found in Europe and Asia. The mortality of BP is lower in the United States than Europe, but higher than previous estimates.

The full text of this article is available in PDF format.

Key words : autoimmune blistering disorder, bullous pemphigoid, epidemiology, geriatric, incidence, mortality

Abbreviations used : BP, CI, ELISA



 This study was made possible by the Rochester Epidemiology Project (grant number R01 AG034676 from the National Institute on Aging).
 Conflicts of interest: None declared.



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