Cutaneous reactions to chemotherapeutic drugs and targeted therapies for cancer : Part I. Conventional chemotherapeutic drugs - 16/07/14
Abstract |
Conventional chemotherapy continues to be an important part of cancer management, but may cause various cutaneous reactions because it disturbs specific cell cycle phases. The alkylating agents cyclophosphamide, ifosfamide, and thiotepa can produce hyperpigmentation, while hypersensitivity reactions can be seen with platinum alkylating agents. Antimetabolites vary in reactions from exanthematous to bullous skin lesions. 5-fluorouracil and its derivatives and liposomal doxorubicin and daunorubicin are characteristically known to cause hand-foot syndrome, while bleomycin can cause fibrosis and flagellate dermatitis. Several hypersensitivity reactions may also occur from mitotic inhibitors and topoisomerase inhibitors. These different characteristic presentations are important to dermatologists in identifying the correct diagnosis and management for the cancer patient.
Le texte complet de cet article est disponible en PDF.Key words : cancer, chemotherapy, cutaneous reactions, cytotoxic therapy, drug hypersensitivity, rash
Abbreviations used : 5-FU, CLL, HFS, NHL, NSCLC
Plan
Funding sources: None. |
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Dr Roh was a consultant for World Care. Dr Reyes-Habito has no conflicts of interest to declare. |
Vol 71 - N° 2
P. 203.e1-203.e12 - août 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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