Leishmania tropica in children: A retrospective study - 16/07/14
, Eli Schwartz, MD, DTMH b, c, Felix Pavlotsky, MD a, c, Nicole Sakka, MD a, Aviv Barzilai, MD, MSc a, c, Shoshana Greenberger, MD, PhD a, cAbstract |
Background |
Limited data are available regarding topical and systemic therapies for Leishmania tropica in children.
Objective |
We sought to characterize the clinical presentation and evaluate the efficacy and safety of topical and systemic treatments in pediatric patients infected with L tropica.
Methods |
A retrospective study was performed on 47 children with L tropica cutaneous leishmaniasis. Treatments included topical or systemic therapy with liposomal amphotericin B or pentavalent antimony.
Results |
Seventy patients with L tropica cutaneous leishmaniasis were treated at our center between 2008 and 2012, of which 47 (67%) were children. The average age of the pediatric population was 8.8 years, and the face was the most common site of involvement (76%). The average number of lesions was 2.6. 24 children (51%) required systemic therapy. The patients were treated with 3 to 5 mg/kg/d of intravenous liposomal amphotericin B, and a response was observed in 83% of the patients within 3 months.
Limitations |
This was a retrospective study.
Conclusion |
The disease burden of L tropica in children is high, and because of facial involvement and a low response to topical therapies, systemic therapy is often required. In our experience, liposomal amphotericin B treatment in children is safe and effective and is required for a considerably shorter duration than treatment with pentavalent antimony.
Le texte complet de cet article est disponible en PDF.Key words : children, cryotherapy, intralesional, Leishmania tropica, liposomal amphotericin B, paromomycin ointment, sodium stibogluconate
Abbreviations used : CL, IL, IV, L-AmB, SSG
Plan
| Dr Greenberger is supported by Talpiot Medical Leadership Program, Chaim Sheba Medical Center. |
|
| Conflicts of interest: None declared. |
Vol 71 - N° 2
P. 271-277 - août 2014 Retour au numéro
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