Primary cutaneous follicle center lymphoma with diffuse CD30 expression: A report of 4 cases of a rare variant - 14/08/14
, Dmitry V. Kazakov, MD, PhD a, c, Arno Rütten, MD d, Rudolf A. Rupec, MD, PhD e, f, Petr Talarcik, MD g, Veronika Ballová, MD h, Katrin Kerl, MD b, Reinhard Dummer, MD b, Stephan Lautenschlager, MD i, Dieter R. Zimmermann, PhD j, Marianne Tinguely, MD aAbstract |
Background |
CD30 is expressed in aggressive and Epstein–Barr virus–associated forms of B-cell non-Hodgkin lymphomas, but is rarely expressed by the majority of tumor cells in primary cutaneous B-cell lymphomas (CBCLs). The expression of CD30 in CBCLs may be at risk for misinterpretation as an unequivocal indicator of a highly aggressive form of the disease.
Objective |
We report 4 cases of low malignant primary cutaneous follicle center lymphoma (PCFCL) with diffuse and strong expression of CD30 by the majority of neoplastic cells.
Results |
The patients included 3 men and 1 woman with tumors on the scalp (3 patients) and chest wall (1 patient). The histologic examinations revealed a mixed, diffuse, and follicular growth pattern with CD20+, bcl-6+, and bcl-2− tumor cells. Seventy percent to 90% of the tumor cells expressed CD30. Clonal rearrangement of immunoglobulin heavy chain genes was found in 1 of 4 cases. None of the 3 cases yielded positivity for Epstein–Barr virus RNA.
Limitations |
The study is limited by the small number of patients.
Conclusions |
This rare variant of CD30+ PCFCL needs be distinguished from CD30+ aggressive B-cell lymphomas. CD30 in this variant of CBCLs may serve as a therapeutic target for anti-CD30 antibody–based strategies.
Le texte complet de cet article est disponible en PDF.Key words : CD30, cutaneous lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Gorlin–Goltz syndrome, PTCH
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 71 - N° 3
P. 548-554 - septembre 2014 Retour au numéro
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