The natural history of chronic urticaria in childhood: A prospective study - 17/09/14
Abstract |
Background |
There are few prospective studies on the natural course of chronic urticaria (CU) in children.
Objective |
We sought to examine the natural history of CU in children and to identify predictors for remission.
Methods |
Children 4 to 15 years of age with CU were investigated with a complete blood cell count, erythrocyte sedimentation rate, antinuclear antibody titer, complement CH50 level, thyroid studies, autologous serum skin test, skin-prick tests, food challenges, and stool examination for parasites. They were considered to be in remission if symptoms did not recur for at least 12 months without medication.
Results |
In all, 92 children (53.3% female) with CU were recruited and followed up for a median duration of 4.3 years (range 2.5-5.8 years). Chronic autoimmune urticaria (CAU) was identified in 40% of the patients. Food allergy was found in 8.7% and parasitic infestations in 5.4%. Remission rates at 1, 3, and 5 years after the onset of CU symptoms were 18.5%, 54%, and 67.7%, respectively. The remission rate did not differ in CAU compared with non-CAU. No predictor of CU remission was identified.
Limitations |
The basophil histamine release assay was not performed.
Conclusion |
Children with CU have a favorable outcome. CAU did not have an intractable course.
Le texte complet de cet article est disponible en PDF.Key words : autologous serum skin test, autoreactivity, children, chronic spontaneous urticaria, chronic urticaria, food allergy, natural course, remission
Abbreviations used : ANA, ASST, CAU, CSU, CU, SPT
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 71 - N° 4
P. 663-668 - octobre 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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