Mortality of patients with bullous pemphigoid in Korea - 17/09/14
Abstract |
Background |
The reported mortality rates and prognoses of bullous pemphigoid (BP) vary among different countries. However, the mortality rate of BP has not been investigated in Korea.
Objective |
We sought to evaluate the mortality rate of Korean patients with BP in comparison to that of an age-matched general population in Korea, and to identify prognostic factors affecting overall survival.
Methods |
We conducted a retrospective analysis of 168 patients diagnosed with BP between 1993 and 2013 at Gangnam Severance Hospital in Seoul, Korea.
Results |
The 1-, 2-, and 5-year mortality rates of BP patients were 19.46% (95% confidence interval [CI], 13.83-27.00), 29.13% (95% CI, 21.91-38.08), and 58.03% (95% CI, 47.04-69.45), respectively. The median age was 73 years (range, 6-99 years). The standardized mortality ratio ranged from 2.43 (95% CI, 0.12-11.96) to 9.56 (95% CI, 2.43-26.02), depending on the age group. In multivariate analysis, old age at the time of diagnosis, stroke, diabetes, and delayed diagnosis were associated with increased mortality.
Limitations |
This study was conducted as a retrospective analysis and was based at a single institution.
Conclusion |
The mortality rate of patients with BP is significantly higher than that for the general population.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune bullous disease, bullous pemphigoid, Korea, mortality, prognosis
Abbreviations used : BP, CI, SMR
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 71 - N° 4
P. 676-683 - octobre 2014 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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