Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: A randomized, single-blind, split-face study - 17/09/14
, Kwang Ho Kim, MD a, Kwang Joong Kim, MD aAbstract |
Background |
Chlorophyll-a is a novel photosensitizer recently tested for the treatment of acne vulgaris.
Objective |
We sought to evaluate the clinical efficacy and safety of chlorophyll-a photodynamic therapy used for acne treatment.
Methods |
Subjects with acne on both sides of the face were included. Eight treatment sessions were performed over a 4-week duration. Half of the face was irradiated using a blue and red light-emitting diode after topical application of chlorophyll-lipoid complex. The other half underwent only light-emitting diode phototherapy. The lesion counts and acne severity were assessed by a blinded examiner. Sebum secretion, safety, and histologic changes were also evaluated.
Results |
In total, 24 subjects completed the study. Facial acne improved on both treated sides. On the chlorophyll-a photodynamic therapy–treated side, there were significant reductions in acne lesion counts, acne severity grades, and sebum levels compared with the side treated with light-emitting diode phototherapy alone. The side effects were tolerable in all the cases.
Limitations |
All the subjects were of Asian descent with darker skin types, which may limit the generalizability of the study. A chlorophyll-a arm alone is absent, as is a no-treatment arm.
Conclusions |
We suggest that chlorophyll-a photodynamic therapy for the treatment of acne vulgaris can be effective and safe with minimal side effects.
Le texte complet de cet article est disponible en PDF.Key words : acne vulgaris, chlorophyll-a, light-emitting diode, photodynamic therapy, photosensitizer, treatment
Abbreviations used : ALA, LED, MAL, PDT
Plan
| Funding sources: None. |
|
| The first two authors contributed equally to this work. |
|
| Conflicts of interest: None declared. |
Vol 71 - N° 4
P. 764-771 - octobre 2014 Retour au numéro
Article précédent
- Reliability of Clinician Erythema Assessment grading scale
- Jerry Tan, Hong Liu, James J. Leyden, Matthew J. Leoni
- Obstacles hindering the mainstream practice of teledermatopathology
- Danielle Giambrone, Babar K. Rao, Amin Esfahani, Shaan Rao
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?