Article

5 Iconography
Access to the text (HTML) Access to the text (HTML)
PDF Access to the PDF text
Advertising


Access to the full text of this article requires a subscription.
  • If you are a subscriber, please sign in 'My Account' at the top right of the screen.

  • If you want to subscribe to this journal, see our rates



Journal of the American Academy of Dermatology
Volume 71, n° 6
pages 1077-1082 (décembre 2014)
Doi : 10.1016/j.jaad.2014.08.026
accepted : 18 August 2014
Original Articles

Clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas: The Yale University Spitzoid Neoplasm Repository experience, 1991 to 2008
 

Jason P. Lott, MD, MHS, MSHP a, f, Jade Wititsuwannakul, MD g, Julie J. Lee, MPH h, Stephan Ariyan, MD, MBA b, c, Deepak Narayan, MD b, c, Harriet H. Kluger, MD b, d, Rossitza Lazova, MD b, e,
a Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 
c Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 
d Section of Medical Oncology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 
e Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 
b Yale Cancer Center, New Haven, Connecticut 
f Section of Dermatology, Veterans Administration Connecticut Healthcare System, West Haven, Connecticut 
g Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand 
h University of Southern California, Keck School of Medicine, Los Angeles, California 

Reprint requests: Rossitza Lazova, MD, Yale Dermatopathology Laboratory, 15 York St, PO Box 208059, New Haven, CT 06510.
Abstract
Background

Spitz nevi and Spitzoid malignant melanomas are uncommon and may be difficult to distinguish histopathologically. Identification of clinical features associated with these lesions may aid in diagnosis.

Objective

We sought to identify clinical characteristics associated with Spitz nevi and Spitzoid malignant melanomas.

Methods

We conducted a retrospective cohort study of Spitz nevi and Spitzoid malignant melanomas from the Yale University Spitzoid Neoplasm Repository diagnosed from years 1991 through 2008. Descriptive statistics and multivariate logistic regression were used to compare select patient- and tumor-level factors associated with each lesion.

Results

Our cohort included 484 Spitz nevi and 54 Spitzoid malignant melanomas. Spitz nevi were more common (P  = .03) in females (65%; n = 316) compared with Spitzoid malignant melanomas (50%; n = 27), occurred more frequently in younger patients (mean age at diagnosis 22 vs 55 years; P < .001), and more likely presented as smaller lesions (diameter 7.6 vs 10.5 mm; P < .001). Increasing age (odds ratio 1.16, 95% CI [1.09, 1.14]; P < .001) and male gender (odds ratio 2.77, 95% CI [1.17, 6.55]; P < .02) predicted Spitzoid malignant melanoma diagnosis.

Limitations

Small sample size, unmeasured confounding, and restriction to a single institution may limit the accuracy and generalizability of our findings.

Conclusions

Age and gender help predict diagnosis of Spitz nevi and Spitzoid malignant melanomas.

The full text of this article is available in PDF format.

Key words : clinical characteristics, diagnosis, epidemiology, Spitz nevus, Spitzoid malignant melanoma, Yale Spitzoid Neoplasm Repository



 Funding sources: None.
 Conflicts of interest: None declared.



© 2014  American Academy of Dermatology, Inc.@@#104156@@
EM-CONSULTE.COM is registrered at the CNIL, déclaration n° 1286925.
As per the Law relating to information storage and personal integrity, you have the right to oppose (art 26 of that law), access (art 34 of that law) and rectify (art 36 of that law) your personal data. You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted.
Personal information regarding our website's visitors, including their identity, is confidential.
The owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.
Close
Article Outline
You can move this window by clicking on the headline