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Journal of the American Academy of Dermatology
Volume 71, n° 6
pages 1093-1101 (décembre 2014)
Doi : 10.1016/j.jaad.2014.09.018
accepted : 8 September 2014
Original Articles

Mortality in women with pregnancy-associated malignant melanoma
 

Anna L.V. Johansson, MSc a, , Therese M-L. Andersson, PhD a, Anna Plym, MSc a, Gustav J. Ullenhag, MD, PhD b, Henrik Møller, Dr Med c, Mats Lambe, MD, PhD a, d
a Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden 
b Department of Radiology, Oncology, and Radiation Science, Section of Oncology, Uppsala University, Uppsala, Sweden 
c Cancer Epidemiology and Population Health, King's College London, London, United Kingdom 
d Regional Cancer Center, Uppsala, Sweden 

Reprint requests: Anna L. V. Johansson, MSc, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE-17177 Stockholm, Sweden.
Abstract
Background

Malignant melanoma (MM) is one of the most common malignancies in young women. It remains debated whether a MM diagnosed during pregnancy or lactation has a worse prognosis.

Objective

We sought to examine mortality in women with pregnancy-associated MM (PAMM) (diagnosed during pregnancy and up to 2-years postpartum).

Methods

This was a population-based cohort study based on information retrieved from the Swedish Cancer and Multi-Generation Registers. Hazard ratios with 95% confidence intervals adjusted for age, period, education, parity, and tumor location were estimated.

Results

In total, 6857 women and girls aged 15 to 44 years with a diagnosis of cutaneous MM between 1963 and 2009 were identified. Of these, 1019 cases were classified as PAMM. The cause-specific mortality did not differ between PAMM and MM not diagnosed near childbirth (adjusted hazard ratio 1.09, 95% confidence interval 0.83-1.42).

Limitations

Information on stage at diagnosis was available only for a subset of patients

Conclusion

Overall, the cause-specific mortality in women and girls with PAMM did not differ from that in women and girls with non-PAMM. The current findings do not provide evidence of an adverse prognostic influence of pregnancy or a recent birth.

The full text of this article is available in PDF format.

Key words : malignant melanoma, mortality, pregnancy, stage, survival, Sweden

Abbreviations used : CI, FPM, HR, MM, PAMM



 Supported by a grant from Karolinska Institutet Funds.
 Conflicts of interest: None declared.



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