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Journal of the American Academy of Dermatology
Volume 71, n° 6
pages 1212-1217 (décembre 2014)
Doi : 10.1016/j.jaad.2014.08.015
accepted : 11 August 2014

Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients

Megha M. Tollefson, MD a, Marian T. McEvoy, MD a, Rochelle R. Torgerson, MD, PhD a, Alina G. Bridges, DO a, b,
a Department of Dermatology, Mayo Clinic, Rochester, Minnesota 
b Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 

Reprint requests: Alina G. Bridges, DO, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Diffuse dermal angiomatosis (DDA) is a rare skin condition considered to be a type of reactive angioendotheliomatosis. Histologic features are quite characteristic. It has been reported in association with vaso-occlusive disease, trauma, or underlying hypercoagulability. In the past, it was thought to be most common on the lower extremities.


The purpose of this study was to describe the clinical and histologic features of 5 patients with DDA.


The clinical and histologic features of 5 patients with DDA were evaluated.


Five women (47-58 years old) had DDA of the breast. Histologic examination showed a diffuse proliferation of benign endothelial cells between the collagen bundles throughout the dermis.


The main limitation of our study is the limited number of patients.


Involvement of the breast is much more common than previously reported. Smoking seems to be a strong risk factor for the disease. Revascularization, oral corticosteroids, and oral anticoagulation have all been reported to be somewhat successful in the treatment of DDA of the breast.

The full text of this article is available in PDF format.

Key words : breast, breast reduction mammaplasty, dermal angiomatosis, reactive angioendotheliomatosis, vascular proliferation, vaso-occlusive disease

 Funding sources: None.
 Conflicts of interest: None declared.

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