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Journal of the American Academy of Dermatology
Volume 71, n° 6
pages 1212-1217 (décembre 2014)
Doi : 10.1016/j.jaad.2014.08.015
accepted : 11 August 2014
Dermatopathology

Diffuse dermal angiomatosis of the breast: Clinicopathologic study of 5 patients
 

Megha M. Tollefson, MD a, Marian T. McEvoy, MD a, Rochelle R. Torgerson, MD, PhD a, Alina G. Bridges, DO a, b,
a Department of Dermatology, Mayo Clinic, Rochester, Minnesota 
b Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 

Reprint requests: Alina G. Bridges, DO, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Abstract
Background

Diffuse dermal angiomatosis (DDA) is a rare skin condition considered to be a type of reactive angioendotheliomatosis. Histologic features are quite characteristic. It has been reported in association with vaso-occlusive disease, trauma, or underlying hypercoagulability. In the past, it was thought to be most common on the lower extremities.

Objective

The purpose of this study was to describe the clinical and histologic features of 5 patients with DDA.

Methods

The clinical and histologic features of 5 patients with DDA were evaluated.

Results

Five women (47-58 years old) had DDA of the breast. Histologic examination showed a diffuse proliferation of benign endothelial cells between the collagen bundles throughout the dermis.

Limitations

The main limitation of our study is the limited number of patients.

Conclusion

Involvement of the breast is much more common than previously reported. Smoking seems to be a strong risk factor for the disease. Revascularization, oral corticosteroids, and oral anticoagulation have all been reported to be somewhat successful in the treatment of DDA of the breast.

The full text of this article is available in PDF format.

Key words : breast, breast reduction mammaplasty, dermal angiomatosis, reactive angioendotheliomatosis, vascular proliferation, vaso-occlusive disease



 Funding sources: None.
 Conflicts of interest: None declared.



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