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Journal of the American Academy of Dermatology
Volume 71, n° 6
pages 1234-1240 (décembre 2014)
Doi : 10.1016/j.jaad.2014.07.026
accepted : 19 July 2014

The deep penetrating nevus

Lauren Strazzula, BA a, Maryanne Makredes Senna, MD b, Mariko Yasuda, MD b, Leah Belazarian, MD b, c,
a University of Massachusetts Medical School, Worcester, Massachusetts 
b Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, UMass Memorial Healthcare, Worcester, Massachusetts 
c Division of Dermatology, Department of Pediatrics, University of Massachusetts Medical School, UMass Memorial Healthcare, Worcester, Massachusetts 

Reprint requests: Leah Belazarian, MD, UMass Memorial Healthcare, 281 Lincoln St, Worcester, MA 01605.

The deep penetrating nevus (DPN), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life. Histopathologically, the DPN is wedge-shaped and contains melanocytes that exhibit deep infiltration into the dermis. Given these features, DPN may clinically and histopathologically mimic malignant melanoma, sparking confusion about the appropriate evaluation and management of these lesions. The goal of this review is to summarize the clinical and histopathological features of DPN and to discuss diagnostic and treatment strategies for dermatologists.

The full text of this article is available in PDF format.

Key words : deep penetrating nevus, dermatopathology, malignant melanoma, melanocytic tumor of uncertain malignant potential, nevus with focal atypical epithelioid components, plexiform spindle cell nevus

 Funding sources: None.
 Conflicts of interest: None declared.

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