A split-face evaluation of a novel pigment-lightening agent compared with no treatment and hydroquinone - 13/12/14
Abstract |
Background |
Lignin peroxidase is a cosmetic skin-lightening alternative that breaks down plant cell walls and melanin.
Objective |
This research examined the topical efficacy of lignin peroxidase in pigment lightening.
Methods |
Sixty women aged 18 to 65 years with mild to moderate facial dyspigmentation were enrolled for 12 weeks in 2 cohorts. Cohort 1 applied lignin peroxidase to 1 randomized side of the face and nothing to the opposite side. Cohort 2 applied lignin peroxidase to 1 facial side and generic hydroquinone to the other. Investigator, subject, and dermospectrophotometer measurements were obtained.
Results |
In cohort 1, improved skin texture (P < .001), roughness (P < .001), and overall appearance (P = .002) was noted at week 2 with lignin peroxidase versus no treatment. By week 12, there was a decrease in spot size with lignin peroxidase versus no treatment (P = .014). This was confirmed by a statistically significant reduction in melanin scores with the dermospectrophotometer on lignin peroxidase–treated side at weeks 4, 8, and 12 (P = .003) and a similar reduction in Melasma Area Severity Index score. Cohort 2 demonstrated parity between lignin peroxidase and hydroquinone, but lignin peroxidase was statistically superior in skin texture and roughness.
Limitations |
The sample size was limited.
Conclusions |
Lignin peroxidase might be an over-the-counter skin-lightening preparation with efficacy parity to hydroquinone.
Le texte complet de cet article est disponible en PDF.Key words : hydroquinone alternatives, lignin peroxidase, skin lightening
Plan
| Funding for this research was provided by a grant from Syneron. |
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| Disclosure: Syneron, which funded this study, is the manufacturer of the product tested. |
Vol 72 - N° 1
P. 105-107 - janvier 2015 Retour au numéro
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