Dysplastic nevi, cutaneous melanoma, and other skin neoplasms in patients with myotonic dystrophy type 1: A cross-sectional study - 13/12/14
, Gabriella Silvestri, MD b, Simona Manco, MD, PhD a, Katy Khamis, MD a, Marcella Masciullo, MD b, d, Maria Laura Ester Bianchi, MD b, Antonello Damiani, MD e, Massimo Santoro, BSBio f, Dennis Linder, MD g, h, Anthony Bewley, MD c, Claudio Feliciani, MD iAbstract |
Background |
Myotonic dystrophy type 1 (MD1) is reported to be associated with internal malignancies. The association of myotonic dystrophy with cutaneous tumors is not fully understood.
Objective |
We sought to explore the total nevi count and the presence of atypical nevi, cutaneous melanoma, and other skin neoplasms in a representative cohort of patients with MD1 and to compare the findings with age- and sex-matched control subjects.
Methods |
In all, 90 patients with MD1 and 103 age- and sex-matched control subjects were assessed for cutaneous neoplasms by clinical skin and epiluminescence examination (dermoscopy). Where indicated, subsequent excisions were performed. In patients with MD1, leukocyte n(CTG) expansion was measured.
Results |
Patients with MD1 showed significantly higher numbers of nevi, dysplastic nevi, and melanomas despite a significantly greater proportion of the control subjects reporting sunburns. In addition, we found a significantly greater number of pilomatrixoma in patients with MD1.
Limitations |
Our study is limited by the fact that there is no agreed-upon standardized technique to assess for prior sun exposure. Further research in the association of cutaneous neoplasms and MD1 including vitamin D and molecular biological techniques are also recommended.
Conclusion |
MD1 itself may predispose to development of skin tumors.
Le texte complet de cet article est disponible en PDF.Key words : dermoscopy, dysplastic nevus, melanoma, myotonic dystrophy, nonmelanoma skin cancer, pilomatrixoma, skin cancer, Steinert disease
Abbreviations used : CM, MD1, NMSC
Plan
| Drs Zampetti and Silvestri contributed equally to this work. |
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| Supported by the Italian Ministry of University and Scientific Research (line D1-2012). |
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| Conflicts of interest: None declared. |
Vol 72 - N° 1
P. 85-91 - janvier 2015 Retour au numéro
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