Viral infections in acute graft-versus-host disease: A review of diagnostic and therapeutic approaches - 14/03/15
Abstract |
Background |
While immunosuppressive therapy for acute graft-versus-host disease (aGVHD) advances, viral reactivation has been found to be an increasingly common complication in these patients. Dermatologists may often be consulted on inpatient services for evaluation.
Objective |
We investigated the literature for the role of viral infections in aGVHD and review the current evidence regarding management.
Methods |
Articles in the public domain regarding aGVHD, cytomegalovirus, Epstein–Barr virus, varicella zoster virus, hepatitis viruses, parvovirus B19, and respiratory viruses were included.
Results |
Dermatologic findings vary between different viral antigens, and some infections may be a marker for the development of aGVHD or worsen prognosis.
Limitations |
The heterogeneous cohorts of the studies reviewed often preclude direct comparison between results.
Conclusion |
The relationship between viral reactivation and aGVHD may be bidirectional and is worthy of further exploration. Additional studies are needed to determine appropriate prophylaxis and treatment.
Le texte complet de cet article est disponible en PDF.Key words : cytomegalovirus, Epstein–Barr virus, graft-versus-host disease, human herpesvirus 6, human herpesvirus 7, inpatient dermatology, transplant dermatology, viral infections
Abbreviations used : aGVHD, CMV, EBV, HBV, HCV, HHV6, LAD, LCV, RSV, VZV
Plan
Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 72 - N° 4
P. 696-702 - avril 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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