A clinical, histopathologic, and outcome study of melanonychia striata in childhood - 17/04/15
Abstract |
Background |
The current literature suggests that approximately 5% to 10% of melanonychia striata cases in adults are the result of subungual melanoma.
Objective |
We sought to evaluate the clinical and histopathologic features and to determine the outcomes and causes of melanonychia striata in a cohort of children.
Methods |
We assessed 30 childhood cases of melanonychia striata for features typically associated with melanoma such as Hutchinson sign, width of the pigmented band, evolution, color, and nail dystrophy. We assessed the histopathology of lesional biopsy specimens, including melanocyte counts and suprabasal movement of melanocytes. Clinical follow-up information was reviewed when available.
Results |
Histopathologic diagnoses included subungual lentigo in 20 cases, subungual nevus in 5 cases, and atypical melanocytic hyperplasia in 5 cases. Although a number of cases exhibited worrisome clinical or histopathologic features, none showed evidence of aggressive behavior or warranted a diagnosis of melanoma.
Limitations |
The sample size and follow-up times are limited.
Conclusions |
Melanonychia striata is typically associated with benign stable melanocytic proliferations in childhood. The overwhelming majority of cases can be managed conservatively. Biopsy is required in select cases.
Le texte complet de cet article est disponible en PDF.Key words : longitudinal melanonychia, melanonychia striata, subungual lentigo, subungual melanoma, subungual nevus
Plan
| Supported by the Irene D. Pritzker Foundation. |
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| Disclosures: Dr Gerami has served as a consultant to Castle Biosciences Inc, Myriad Genetics, and DermTech Inc, and has received honoraria for this. Dr Guitart has served as a consultant to Castle Biosciences Inc and has received honoraria for this. Ms Cooper, Drs Arva, Yélamos, Wagner, and Shen, Ms Lee, Ms Obregon, and Ms Sholl have no conflicts of interest to declare. |
Vol 72 - N° 5
P. 773-779 - mai 2015 Retour au numéro
Article précédent
- A message from the Editor
- Gene expression profiling for molecular staging of cutaneous melanoma in patients undergoing sentinel lymph node biopsy
- Pedram Gerami, Robert W. Cook, Maria C. Russell, Jeff Wilkinson, Rodabe N. Amaria, Rene Gonzalez, Stephen Lyle, Gilchrist L. Jackson, Anthony J. Greisinger, Clare E. Johnson, Kristen M. Oelschlager, John F. Stone, Derek J. Maetzold, Laura K. Ferris, Jeffrey D. Wayne, Chelsea Cooper, Roxana Obregon, Keith A. Delman, David Lawson
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