Practical application of new technologies for melanoma diagnosis : Part II. Molecular approaches - 16/05/15
Abstract |
The criterion standard for diagnosing cutaneous melanoma continues to be histologic examination. However, classifying some melanocytic lesions by conventional microscopy can be problematic if they exhibit some architectural or morphologic characteristics of both nevus and melanoma. Moreover, histologic appearance does not always predict biologic behavior. There is therefore a need and opportunity to develop new technologies that can facilitate the histologic diagnosis of melanoma and potentially help distinguish lesions with a lesser or greater risk of metastasis. In part II of this 2-part continuing medical education article, we will review the molecular technologies currently available for facilitating melanoma diagnosis, including comparative genomic hybridization, fluorescence in situ hybridization, and epidermal genetic retrieval. Our goal is to provide the clinician with an up to date understanding of these molecular approaches so that they can be applied to their management of challenging melanocytic lesions.
Le texte complet de cet article est disponible en PDF.Key words : fluorescence, genomic, hybridization, melanoma, molecular, nevus
Abbreviations used : CGH, EGIR, FISH
Plan
Dr Grossman is supported by the University of Utah Department of Dermatology and the Huntsman Cancer Foundation. Mr March is supported by an award from the University of Nevada School of Medicine Office of Medical Research. |
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Conflicts of interest: None declared. |
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Date of release: June 2015 |
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Expiration date: June 2018 |
Vol 72 - N° 6
P. 943-958 - juin 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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