Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis - 16/05/15
Abstract |
Background |
There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD).
Objective |
To assess the risk of lymphoma and the role of topical treatments in patients with AD.
Methods |
A systematic literature search and a separate meta-analysis were performed on case control and cohort studies.
Results |
Of the 3979 articles retrieved, 24 references met the inclusion criteria. In cohort studies, the risk of lymphoma was slightly increased, with a relative risk (RR) of 1.43 (95% confidence interval [CI], 1.12-1.81). In case control studies, no significant increased risk of lymphoma was found, with an odds ratio (OR) of 1.18 (95% CI, 0.94-1.47). Severity of AD was a significant risk factor. Highly potent topical steroids were associated with an increased risk of lymphoma. For topical calcineurin inhibitors (TCIs), a significant association between tacrolimus and mostly skin lymphoma was found in 1 study.
Limitations |
Confusion between severe AD and cutaneous T-cell lymphoma may account for part of the increased risk of lymphoma in patients with AD.
Conclusion |
This systematic literature review shows a slightly increased risk of lymphoma in patients with AD. Severity of AD appears to be a significant risk factor. The role of topical steroids and TCIs is unlikely to be significant.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, lymphoma, neoplasm, pimecrolimus, systematic review, tacrolimus, topical corticosteroids
Abbreviations used : AD, CI, CTCL, OR, RR, SIR, TCI, TCS
Plan
| Funding sources: None. |
|
| Dr Paul is consultant and investigator for Astellas and Novartis. Dr Meyer is a speaker for and on the advisory board of Roche and BMS, on the advisory board for Amgen, and is a speaker for MSD and AbbVie. None of the grants or honoraria were directly related to this study. Drs Legendre, Barnetche, Mazereeuw-Hautier, and Murrell have no conflicts of interest to declare. |
Vol 72 - N° 6
P. 992-1002 - juin 2015 Retour au numéro
Article précédent
- Liver injury in patients with DRESS: A clinical study of 72 cases
- I-Chun Lin, Hung-Chih Yang, Carol Strong, Che-Wen Yang, Yung-Tsu Cho, Kai-Lung Chen, Chia-Yu Chu
- Sézary syndrome without erythroderma
- Aurélia Henn, Laurence Michel, Charlotte Fite, Lydia Deschamps, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Eduardo Marinho, Marie Beylot-Barry, Martine Bagot, Liliane Laroche, Béatrice Crickx, Eve Maubec
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?