Dysplastic nevus: Fact and fiction - 17/08/15
Abstract |
The term “dysplastic nevus” (DN) implies that this nevus exists as a distinct and defined entity of potential detriment to its host. We examine the current data, which suggest that this entity exists as histologically and possibly genetically different from common nevus, with some overlapping features. Studies show that a melanoma associated with a nevus is just as likely to arise in a common nevus as in DN. Furthermore, there is no evidence that a histologically defined DN evolves into a melanoma or that the presence of 1 or more DN on an individual patient confers any increased melanoma risk. We suggest that the term “dysplastic nevus” be abandoned so that the focus can shift to confirmed and relevant indicators of melanoma risk, including high nevus counts and large nevus size.
Le texte complet de cet article est disponible en PDF.Key words : B-K mole syndrome, BRAF, common nevus, congenital melanocytic nevus, cyclin-dependent kinase inhibitor 2A (CDKN2A), dysplastic nevus, familial atypical multiple-mole melanoma, melanoma, p16, p53
Abbreviations used : CMN, CN, DN, DNS, NIH, WHO
Plan
Funding sources: None. |
|
Conflicts of interest: None declared. |
Vol 73 - N° 3
P. 507-512 - septembre 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?