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Journal of the American Academy of Dermatology
Volume 74, n° 1
pages 120-126 (janvier 2016)
Doi : 10.1016/j.jaad.2015.08.024
accepted : 12 August 2015
Original Articles

Increasing incidence of infantile hemangiomas (IH) over the past 35 years: Correlation with decreasing gestational age at birth and birth weight
 

Katelyn R. Anderson, MD a, Jennifer J. Schoch, MD a, Christine M. Lohse, MS c, Jennifer L. Hand, MD a, b, d, Dawn M. Davis, MD a, b, Megha M. Tollefson, MD a, b,
a Department of Dermatology, Mayo Clinic, Rochester, Minnesota 
b Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 
c Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 
d Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota 

Reprint requests: Megha M. Tollefson, MD, Mayo Clinic, 200 First St SW, Rochester, MN 55905.
Abstract
Background

Infantile hemangiomas (IH) are the most common soft-tissue tumors of infancy, but little is known regarding their true incidence.

Objectives

We sought to determine the current incidence of IH and examine trends in incidence, demographics, and lesion characteristics over 3 decades.

Methods

The Rochester Epidemiology Project was used to identify infants residing in Olmsted County, Minnesota, who were given a diagnosis of IH between January 1, 1976, and December 31, 2010.

Results

In all, 999 infants were given a diagnosis of IH. Incidence increased over the 3-decade study period from 0.97 to 1.97 per 100 person-years (P  < .001). Average gestational age at birth and birth weight for infants with IH decreased over the study period (39.2-38.3 weeks, P  < .001 and 3383-3185 g, P  = .003, respectively). The overall age- and sex-adjusted incidence of IH was 1.64 per 100 person-years (95% confidence interval 1.54-1.75).

Limitations

The population of Olmsted County, Minnesota, is predominantly non-Hispanic white, limiting our ability to report racial differences in incidence. This was a retrospective study.

Conclusions

This study provides a longitudinal, population-based incidence of IH. Incidence has increased steadily over the past 3 decades, correlating significantly with decreasing gestational age at birth and birth weight in affected infants.

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Key words : hemangioma, incidence, infantile hemangioma, vascular anomaly, vascular birthmark, vascular tumor



 Drs Anderson and Schoch contributed equally in this research.
 Funding sources: Rochester Epidemiology Project NIH grant (NIH R01 AG034676).
 Conflicts of interest: None declared.



© 2015  American Academy of Dermatology, Inc.@@#104156@@