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Journal of the American Academy of Dermatology
Volume 74, n° 6
pages 1135-1143 (juin 2016)
Doi : 10.1016/j.jaad.2015.12.053
accepted : 31 December 2015
Original Articles

Cutaneous anaplastic large-cell lymphoma (ALCL): A comparative clinical feature and survival outcome analysis of 52 cases according to primary tumor site

Woo Jin Lee, MD, PhD a, Ik Jun Moon, MD a, Sang Hyung Lee, MD a, Chong Hyun Won, MD, PhD a, Sung Eun Chang, MD, PhD a, Jee Ho Choi, MD, PhD a, Kee Chan Moon, MD, PhD a, Chan-Sik Park, MD, PhD b, Jooryung Huh, MD, PhD b, Mi Woo Lee, MD, PhD a,
a Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 
b Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 

Reprint requests: Mi Woo Lee, MD, PhD, Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong Songpa-gu, Seoul 138-736, Korea.Department of DermatologyAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Pungnap-dong Songpa-guSeoul138-736Korea

Cutaneous anaplastic large-cell lymphoma (ALCL) is primary extranodal or secondary to nodal disease.


We sought to analyze clinical features and survival outcomes by primary tumor site in patients with cutaneous ALCL.


Clinical features, survival outcomes, and prognostic factors of 52 patients with primary or secondary cutaneous ALCL to primary nodal disease were retrospectively evaluated using medical records.


Although skin lesion characteristics did not significantly differ between groups, the head and neck location was more common in primary cutaneous ALCL, whereas cutaneous lesion extent was greater in secondary cutaneous ALCL. Skin lesion extent in primary cutaneous ALCL was indicative of extracutaneous dissemination development and skin lesion relapse. Neither anaplastic lymphoma kinase expression nor clinical stage affected skin lesion characteristics in secondary cutaneous ALCL. Patients with primary rather than secondary cutaneous ALCL demonstrated better survival outcomes. The skin lesion extent and location on the leg were associated with the tendency toward a poorer prognosis in primary cutaneous ALCL. The secondary cutaneous ALCL prognosis was not influenced by skin lesion characteristics.


This was a retrospective study in a single institution.


Survival outcomes and prognostic factors in cutaneous ALCL differed by primary tumor site.

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Key words : anaplastic large-cell lymphoma, clinical feature, cutaneous lymphoma, prognostic factor, skin, survival outcome

Abbreviations used : ALCL, ALK, PFS

 Funding sources: None.
 Conflicts of interest: None declared.

© 2016  American Academy of Dermatology, Inc.@@#104156@@