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Journal of the American Academy of Dermatology
Volume 74, n° 6
pages 1178-1184 (juin 2016)
Doi : 10.1016/j.jaad.2015.12.049
accepted : 30 December 2015
Original Articles

Follicular vitiligo: A report of 8 cases

Emily Yiping Gan, MRCP (UK) a, b, , Muriel Cario-André, PhD c, Catherine Pain, BTS c, Jean-Francois Goussot, MD d, Alain Taïeb, MD, PhD a, c, Julien Seneschal, MD, PhD a, c, Khaled Ezzedine, MD, PhD a, c
a Department of Dermatology and Pediatric Dermatology, National Center for Rare Skin Disorders, Hôpital Pellegrin-Enfants and Hôpital Saint André, Centre Hospitalier Universitaire (CHU) de Bordeaux, Bordeaux, France 
b National Skin Center, Singapore 
c Inserm U1035, University of Bordeaux, Bordeaux, France 
d Department of Pathology, Hôpital Haut-Lévêque, Pessac, France 

Reprint requests: Emily Yiping Gan, MRCP (UK), National Skin Center, 1 Mandalay Road, Singapore 308205.National Skin Center1 Mandalay RoadSingapore308205

Follicular vitiligo, a recently proposed new subtype of vitiligo, has primary involvement of the hair follicle melanocytic reservoir.


We sought to characterize follicular vitiligo through a case series of 8 patients.


Patients with features of follicular vitiligo who were seen at the vitiligo clinic in the National Center for Rare Skin Disorders in Bordeaux, France, were recruited. A retrospective review of case records and clinical photographs was carried out.


There were 8 male patients with a mean age of 48 years. All patients reported significant whitening of their body and, in some, scalp hairs before cutaneous depigmentation. Examination revealed classic generalized depigmented lesions of vitiligo and an impressive presence of leukotrichia, not only in the vitiliginous areas, but also in areas with clinically normal-appearing skin. Punch biopsy specimen of the leukotrichia and vitiligo lesions demonstrated loss of melanocytes and precursors in the basal epidermis and hair follicle.


This was a cross-sectional study based on a single-center experience.


Follicular vitiligo is a distinct entity within the spectrum of vitiligo. This entity may serve as the missing link between alopecia areata and vitiligo, with probable physiopathological similarities between these conditions.

The full text of this article is available in PDF format.

Key words : alopecia areata, follicular vitiligo, leukotrichia, nonsegmental, poliosis, vitiligo

 Funding sources: None.
 Conflicts of interest: None declared.

© 2016  American Academy of Dermatology, Inc.@@#104156@@