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Journal of the American Academy of Dermatology
Volume 74, n° 6
pages 1220-1233 (juin 2016)
Doi : 10.1016/j.jaad.2015.11.033
accepted : 12 November 2015

Keratoacanthoma (KA): An update and review

Bartlomiej Kwiek, MD, PhD a, , Robert A. Schwartz, MD, MPH b
a Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland 
b Dermatology and Pathology, Rutgers University New Jersey Medical School, and Rutgers University School of Public Affairs and Administration, Newark, New Jersey 

Reprint requests: Bartlomiej Kwiek, MD, PhD, Dermatology and Immunodermatology, Medical University of Warsaw, Koszykowa 82A Street, 02-008 Warsaw, Poland.Dermatology and ImmunodermatologyMedical University of WarsawKoszykowa 82A StreetWarsaw02-008Poland

Keratoacanthoma (KA) is a common but underreported tumor of the skin. Two striking features of KA are its clinical behavior with spontaneous regression after rapid growth and its nosological position on the border between benignity and malignancy. We review current knowledge on the clinical, histopathological, and dermoscopic features of KA to ensure a proper diagnosis and describe its variants, including different types of multiple KAs. We highlight current concepts of KA ethiopathogenesis with special emphasis on the genetic background of multiple familial KA, the role of Wnt signaling pathway, and induction of KA by BRAF inhibitors and procedures of esthetic dermatology. Finally, treatment strategies are presented with surgical excision as a first option, followed by other modalities, including intralesional chemotherapy, topical and systemic agents, lasers, cryotherapy, and photodynamic therapy.

The full text of this article is available in PDF format.

Key words : BRAF inhibitor, erlotinib, Ferguson-Smith, Grzybowski, histopathology, keratoacanthoma, multiple keratoacanthoma, multiple self-healing squamous epithelioma, squamous cell carcinoma, treatment

Abbreviations used : GEKA, KA, MSHSE, MTS, SCC

 Funding sources: None.
 Conflicts of interest: None declared.

© 2015  American Academy of Dermatology, Inc.@@#104156@@