Skin pigmentation from clofazimine therapy in leprosy patients: A reappraisal - 06/10/17
Résumé |
Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.
Le texte complet de cet article est disponible en PDF.Vol 23 - N° 2P1
P. 236-241 - août 1990 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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