Necrobiotic xanthogranuloma with paraproteinemia - 07/10/17
Abstract |
Eight patients had multiple xanthomatous plaques and subcutaneous nodules that had a predilection for the periorbital area, flexures, and trunk and that tended to ulcerate. Skin biopsy specimens showed a combination of xanthogranulomatous nodules with necrobiosis. All patients had an accompanying dysproteinemia, which was a monoclonal IgG paraprotein in six. Hyperlipidemia, low serum complement, and cryoglobulinemia were variable features. Five patients had leukopenia. Bone marrow examination showed myeloma in two patients, a lymphoproliferative process in one, and some atypical plasma cells in two. Cutaneous necrobiotic xanthogranuloma is a distinctive histologic pattern most frequently related to plasma cell dyscrasias, and it should be distinguished from normolipemic plane xanthoma and other necrobiotic granulomas.
Le texte complet de cet article est disponible en PDF.* | The immunoglobulin studies and paraprotein characterization were performed in the laboratory of Robert A. Kyle, M.D., and the immunoperoxidase studies, by Peter M. Banks, M.D. |
Vol 3 - N° 3
P. 257-270 - septembre 1980 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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