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Archives de pédiatrie
Volume 26, n° 1
pages 12-15 (janvier 2019)
Doi : 10.1016/j.arcped.2018.09.013
Received : 9 February 2018 ;  accepted : 30 September 2018
Research papers

Klebsiella pneumoniae and Klebsiella oxytoca meningitis in infants. Epidemiological and clinical features

C. Carrie a, V. Walewski b, c, C. Levy d, e, f, g, C. Alexandre h, J. Baleine i, C. Charreton j, B. Coche-Monier k, L. Caeymaex e, g, F. Lageix a, M. Lorrot l, S. Klosowski m, L. Hess n, O. Zafer o, J. Gaudelus a, f, D. Pinquier f, p, E. Carbonnelle b, c, R. Cohen d, e, f, g, L. de Pontual a, f,
a Service de pédiatrie, hôpitaux universitaires Paris Seine-Saint-Denis (HUPSSD) site Jean Verdier, université Paris XIII, AP–HP, avenue du 14 Juillet, 93140 Bondy, France 
b Service de bactériologie-virologie, hygiène, hôpitaux universitaires de Paris-Seine-Denis (HUPSSD), laboratoire de microbiologie hôpital Avicenne, hôpitaux universitaires de Paris-Seine-Denis (HUPSSD), 125, rue de Stalingrad, 93000 Bobigny, France 
c Université Paris Nord, IAME, UMR 1137, Sorbonne Paris Cité, 75018 Paris, France 
d IMRB GRC GEMINI, ACTIV et université Paris-Est, 27, rue Inkermann, 94100 Saint-Maur-des-Fossés, France 
e Service de médecine néonatale, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France 
f Groupe de pathologie infectieuse pédiatrique, 57, avenue de la Californie, 06200 Nice, France 
g IMRB-GRC GEMINI, université Paris-Est, 40, avenue de Verdun, 94000 Créteil, France 
h Service de néonatologie et réanimation néonatale, 14033 Caen, France 
i Service de pédiatrie néonatale et réanimations, CHU Arnaud de Villeneuve, 371, avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France 
j Service de néonatologie et réanimation néonatale, avenue des Tamaris, 13616 Aix-en-Provence, France 
k Service de pédiatrie, centre hospitalier Simone Veil, 14, rue de Saint-Prix, 95600 Eaubonne, France 
l Service de pédiatrie, hôpital Armand-Trousseau, AP–HP, 26, avenue du Docteur Arnold Netter, 75571 Paris cedex 12, France 
m Service de pédiatrie, 99, route de la Bassée, 62300 Lens, France 
n Service d’urgence et de réanimation pédiatrique, hôpital, 59, boulevard Pinel, 69500 Bron, France 
o Service de pédiatrie, boulevard Laennec, 60100 Creil, France 
p Pediatrie néonatale et réanimation, Pavillon Mère-Enfant, hôpital Charles Nicolle, CHU de Rouen, université de Normandie, 76000 Rouen, France 

Corresponding author. Service de pédiatrie, hôpital Jean Verdier, avenue du 14 Juillet, 93140 Bondy, France.Service de pédiatrie, hôpital Jean Verdieravenue du 14 JuilletBondy93140France

The incidence of meningitis caused by Klebsiella pneumoniae (Kp) and Klebsiella oxytoca (Ko) in high-income countries is unknown, and no series have been published to date.


We conducted a nationwide multicenter observational study in France between 2006 and 2016. All children from the French national registry for paediatric bacterial meningitis under the age of 1 year and hospitalized for Kp or Ko meningitis were included. Virulence factors of four Klebsiella spp. strains were explored by whole genome sequencing.


Of 1859 cases of meningitis in children under the age of 1 year, 13 cases (0.7%) of Klebsiella spp. meningitis (nine for Kp meningitis and four for Ko meningitis) were registered in the French national registry. Three of the patients died and 50% of the survivors had developmental delays.


Prematurity, low birth weight, and congenital anomalies of the urinary tract appear to be risk factors for Klebsiella spp. meningitis as well as virulence factors of the strain.

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Keywords : Klebsiella pneumoniae , Klebsiella oxytoca , Meningitis, Infants

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