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Journal of Stomatology Oral and Maxillofacial Surgery
Volume 120, n° 2
pages 128-132 (avril 2019)
Doi : 10.1016/j.jormas.2018.12.014
Received : 26 June 2018 ;  accepted : 21 December 2018

3D Bioprinting:principles, fantasies and prospects

N Sigaux a, b, , L Pourchet b , P Breton a , S Brosset c , A Louvrier d , CA Marquette b
a Department of maxillofacial and facial plastic surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Claude-Bernard Lyon 1 University, 69310 Pierre-Bénite, France 
b 3d.FAB platform, ICBMS, CNRS 5246 Claude-Bernard Lyon 1 University, 69100 Villeurbanne, France 
c Department of plastic, reconstructive and aesthetic surgery, Croix Rousse Hospital, Hospices Civils de Lyon, Claude-Bernard Lyon 1 University, 69004 Lyon, France 
d Department of Maxillofacial Surgery and Stomatology, Centre Hospitalier Régional Universitaire Jean-Minjoz, 25000 Besançon, France 

Corresponding author at: Centre Hospitalier Lyon Sud, 165, chemin du Grand Revoyet, 69495 Pierre-Bénite, France.Centre Hospitalier Lyon Sud165, chemin du Grand RevoyetPierre-Bénite69495France

Conventional three-dimensional (3D) printing techniques have been growing in importance in the field of reconstructive surgery. Three-dimensional bioprinting is the adaptation of 3D printing techniques to tissue engineering, through the use of a bio-ink containing living cells and biomaterials. We hereby describe the principles of bioprinting, its main current limitations, and the prospects of this technique. A PubMed/MEDLINE search was performed. A total of 40 publications were included. To date, most of the tissues have been printed with promising results in vitro (e.g., skin, cartilage, and muscle). The first animal studies are promising for small-scale defects. Vascularization issues are the main limitation to printing large constructs. Once the barrier of vascularization is overcome, printing organs and composite tissues of any size could be possible, opening the doors for personalized medicine based on medical imaging. Printing custom-made autologous grafts or flaps could minimize donor site morbidity and maximize the morphological results. Considering the potential future applications of bioprinting in the field of reconstructive surgery, one has to be aware of this tool, which could drastically change our practice.

The full text of this article is available in PDF format.

Keywords : Bioprinting, Tissue engineering, 3D Printing, Reconstructive surgical procedures, Microsurgical free flaps, Organ culture techniques

© 2018  Elsevier Masson SAS. All Rights Reserved.