Tissue-sparing properties of Mohs micrographic surgery for infiltrative basal cell carcinoma - 16/05/19
Abstract |
Background |
Mohs micrographic surgery (MMS) should lead to tissue sparing of healthy skin compared with standard surgical excision because smaller surgical margins are used.
Objective |
To quantify the tissue-sparing properties of MMS in primary basal cell carcinoma (BCC) with an infiltrative growth pattern.
Methods |
A prospective study including 256 primary BCCs with an infiltrative growth pattern was performed. Tumor sizes were measured in 2 perpendicular directions. Surface defect areas after MMS were measured. The suspected defect surface area with standard excision using a 5-mm margin was calculated. The primary outcome of this study was the size of the defect surface area spared with MMS compared with the calculated defect surface area with a standard excision.
Results |
The median tumor size was 71 mm2, and the median defect size after MMS was 154 mm2. The median defect size calculated for standard surgical excision was 298 mm2. We have shown that MMS of BCC with an infiltrative growth pattern had a 46.4% tissue-sparing effect when compared with standard surgical excision (95% confidence interval, 43.4%-49.1%; P value < .001).
Limitations |
Single-center study design. Lack of a randomized control group for ethical reasons.
Conclusion |
A rate of tissue sparing of 46% can be reached by using MMS for primary BCC with an infiltrative growth pattern.
Le texte complet de cet article est disponible en PDF.Key words : Mohs micrographic surgery, basal cell carcinoma, tissue sparing
Abbreviations used : BCC, MMS
Plan
| Funding sources: None. |
|
| Conflicts of interest: None disclosed. |
Vol 80 - N° 6
P. 1700-1703 - juin 2019 Retour au numéro
Article précédent
- Randomized phase 3 evaluation of trifarotene 50 ?g/g cream treatment of moderate facial and truncal acne
- Jerry Tan, Diane Thiboutot, Georg Popp, Melinda Gooderham, Charles Lynde, James Del Rosso, Jonathan Weiss, Ulrike Blume-Peytavi, Jolanta Weglovska, Sandra Johnson, Lawrence Parish, Dagmara Witkowska, Nestor Sanchez Colon, Alessandra Alió Saenz, Faiz Ahmad, Michael Graeber, Linda Stein Gold
- Follicular mucinosis in patients with hematologic malignancies other than mycosis fungoides: A clinicopathologic study
- Shamir Geller, Christian J. Gomez, Patricia L. Myskowski, Melissa Pulitzer
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?