Fig. 2.

Fig. 2. : 

Role of the lipogenic pathway in the development of hepatic steatosis. Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver dysfunction, and its incidence has increased markedly over the years. While the mechanisms involved in the pathogenesis of NAFLD in humans have not been thoroughly investigated, enhanced activity of the lipogenic pathway very likely contributes to the development of hepatic steatosis in NAFLD. In response to insulin and glucose, sterol regulatory element-binding protein (SREBP)-1c and carbohydrate responsive element-binding protein (ChREBP) are activated, respectively, and induce the expression of lipogenic genes, including ACC, FAS and SCD1. SREBP-1c and ChREBP are also transactivated by the nuclear receptor LXR that regulates the metabolism of cholesterol and fatty acids. More knowledge of the respective roles of these transcription factors in the pathogenesis of NAFLD is now needed.