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Joint Bone Spine
Volume 71, n° 4
pages 327-330 (juillet 2004)
Doi : 10.1016/S1297-319X(03)00133-7
Received : 8 October 2002 ;  accepted : 7 Mars 2003
Unusual and aggressive thrombotic onset in two children with antiphospholipid-antibody syndrome and systemic lupus erythematosus

Rosa  Roldan-Molina a * ,  Jose  Roman b ,  Alejandro  Escudero a ,  Veronica  Perez-Guijo a ,  Carmen  Castro a ,  Francisco G.  Martinez a ,  Eduardo  Collantes a
aRheumatology Department, Reina Sofia Hospital, Cordoba 14004, Spain 
bHaematology Department, Reina Sofia Hospital, Cordoba 14004, Spain 

*Corresponding author.

We report two pediatric patients with unusual, aggressive initial manifestation of antiphospholipid antibody syndrome secondary to systemic lupus erythematosus. The first patient, a 13-year-old girl, presented with bilateral amaurosis and ischemic cerebral lesions. The second, another 13-year-old girl, presented with cerebral venous sinus thrombosis and membranous glomerulonephritis. Both patients improve after treatment with anticoagulants and immunosuppressive drugs, two therapies that are aimed at modulating the immune response or towards preventing thromboembolic events. However, there is no consensus regarding the duration and intensity of oral anticoagulation in children with antiphospholipid antibody syndrome.

Mots clés  : Antiphospholipid syndrome ; Systemic lupus ertythematosus ; Thrombosis ; Children.

© 2003  Elsevier SAS. All Rights Reserved.