Figure 1



Figure 1 : 

Excitation-contraction signaling in cardiomyocytes with emphasis on targets for gene therapy. Interplay between calcium handling (purple) and β-adrenergic (blue) systems is illustrated. AC: adenylyl cyclase; ATP: adenosine triphosphate; β-AR: beta adrenergic receptor; I-1: (protein phosphatase) inhibitor-1; cAMP: cyclic adenosine monophosphate; Gs: stimulatory G protein; Gi: inhibitory G protein; NCX: sarcolemnal sodium/calcium exchanger; PKA: protein kinase A; PLN: phospholamban; PP: protein phosphatase; RyR: ryanodine receptor; SERCA: sarcoplasmic/endoplasmic reticulum calcium ATPase; SR: sarcoplasmic reticulum.