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Joint Bone Spine
Volume 78, n° 4
pages 337-340 (juillet 2011)
Doi : 10.1016/j.jbspin.2010.10.005
accepted : 8 October 2010
Helicobacter pylori infection and systemic sclerosis–is there a link?

Mislav Radić a, , Dušanka Martinović Kaliterna a, Josipa Radić b
a Department of Rheumatology, University Hospital, Split, Croatia 
b Department of Nephrology, University Hospital, Split, Croatia 

Corresponding author. Šižgorićeva 20, 21 000 Split, Croatia. Tel.: +00385 21 53 26 91/00385 91 89 41 421.

Over the last 20 years, increasing evidence has accumulated to implicate infectious agents in the etiology of systemic sclerosis (SSc) and Raynaud’s phenomenon. Infection rates in patients with SSc compared with those in control populations do not provide clear support for any specific pathogen. However, increased antibody titers, a preponderance of specific strains in patients with SSc, and evidence of molecular mimicry inducing autoimmune responses suggest mechanisms by which infectious agents may contribute to the development and progression of SSc. Helicobacter pylori (H. pylori ) has been associated with diseases such as autoimmune gastritis, Sjögren’s syndrome, atherosclerosis, immune thrombocytopenia purpura, inflammatory bowel diseases and autoimmune pancreatitis, in each of which it seems to play a pathogenetic, but it has also been suggested that it may help to protect against the development of autoimmune gastritis, multiple sclerosis, systemic lupus erythemathosus and inflammatory bowel diseases. A systematic literature search was carried out in MEDLINE, EMBASE, Cochrane Library and ACR/EULAR meeting abstracts. We hypotheses that H. pylori infection might play a critical role in the pathogenesis of SSc. Here we review studies examining the potential involvement of H. pylori infection in SSc.

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Keywords : Systemic sclerosis, Helicobacter pylori , Pathogenesis

© 2010  Société française de rhumatologie@@#104156@@