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Journal of the American Academy of Dermatology
Volume 54, n° 6
pages 951-983 (juin 2006)
Doi : 10.1016/j.jaad.2005.05.004

Toll-like receptors: Applications to dermatologic disease

Sammy S.W. Kang, MD a, Lynda S. Kauls, MD b, , Anthony A. Gaspari, MD c
a From the Department of Dermatology, Weil Medical College, Cornell University 
b Department of Dermatology, Oregon Health and Science University 
c Departments of Dermatology and Microbiology and Immunology, University of Maryland School of Medicine 

Correspondence to: Lynda S. Kauls, MD, Oregon Health and Science University, Department of Dermatology, 3181 SW Sam Jackson Parkway, Mail Code OP-06, Portland, Oregon 97239.

New York, New York; Portland, Oregon; and Baltimore, Maryland


Toll-like receptors are a recently identified group of receptors that are an important component of the immune system. Thus far, ten different receptors have been identified and have unique tissue distribution, ligand binding properties, cellular signaling pathways, and cytokine production profiles. Importantly, ligand binding has been shown to regulate both the adaptive and host immune response; thus, defects in this pathway have the potential to lead to increased susceptibility to infection and inflammatory dysregulation. In this article, the burgeoning literature pertinent to the discovery and signaling mechanisms are reviewed in addition to the discussion of the important role Toll-like receptors may play in the pathogenesis of numerous skin diseases.

Learning objective

At the completion of this learning activity, participants should be familiar with the role of Toll-like receptors in host defenses and their relevance to dermatologic diseases.

The full text of this article is available in PDF format.

Abbreviations used : APC, CMC, DC, GN, HSP, IFN, Ig, IL, IRF, LP, LPS, MAPK, NF-κB, NK, PG, poly-I:C, TH , TIRAP, TNF, TRIF, UV, XP

 Funding Sources: None.
Disclosure: Dr Gaspari has an affiliation with 3M and has received honoraria and grant support from that company.
Reprints not available from the authors.

© 2006  American Academy of Dermatology, Inc.@@#104156@@