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Journal of the American Academy of Dermatology
Volume 57, n° 3
pages 397-400 (septembre 2007)
Doi : 10.1016/j.jaad.2006.07.004
accepted : 6 July 2006

Antiphospholipid antibodies in patients with autoimmune blistering disease

Takeshi Echigo, MD, PhD a, Minoru Hasegawa, MD, PhD a, , Makoto Inaoki, MD, PhD b, Masahide Yamazaki, MD, PhD d, Shinichi Sato, MD, PhD c, Kazuhiko Takehara, MD, PhD a
a From the Departments of Dermatology, Kanazawa University Graduate School of Medical Science 
b Kawasaki Medical School, Kurashiki 
c Nagasaki University Graduate School of Biomedical Sciences 
d Department of Internal Medicine (III), Kanazawa University Graduate School of Medical Science 

Reprint requests: Minoru Hasegawa, MD, PhD, Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan.

Kanazawa, Kurashiki, and Nagasaki, Japan


Our purpose was to determine the serum levels and frequency of antiphospholipid antibodies (aPLs) and confirm the clinical importance of these antibodies in patients with autoimmune blistering disease (ABD).


IgG and IgM anticardiolipin antibodies (aCL), IgG anticardiolipin-β2 glycoprotein I complex antibody (aCL/β2 GPI), and IgG antiphosphatidylserine-prothrombin complex antibody (aPS/PT) were examined with an enzyme-linked immunosorbent assay in 71 patients with ABD, including pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid.


The prevalence of IgG aCL, IgM aCL, aCL/β2 GPI, and IgG aPS/PT was positive for 22.4%, 9.1%, 9.9%, and 25.4% of the ABD patients, respectively, whereas these antibodies were not detected in any of the normal control subjects. Ten of 20 patients with ABD who were attending our hospital in 2004 tested positive for aPLs, and thromboembolism was detected in 7 of 10 patients with aPLs.


Follow-up studies, especially with a large patient group, will be needed to clarify the clinical relevance of aPLs in ABD.


aPLs are frequently detected in patients with ABD. Careful examination and follow-up for thromboembolism may be necessary in ABD patients with aPLs.

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Abbreviations used : ABD, aCL, aCL/β2 GPI, aPL, APS, aPS/PT, BP, PF, PV, SLE

 Funding sources: None.
Conflicts of interest: None declared.

© 2007  American Academy of Dermatology, Inc.@@#104156@@