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Journal of the American Academy of Dermatology
Volume 57, n° 3
pages 502-508 (septembre 2007)
Doi : 10.1016/j.jaad.2006.08.016

Juvenile acanthosis nigricans

Smeeta Sinha, MD, Robert A. Schwartz, MD, MPH
From the Department of Dermatology, New Jersey Medical School 

Reprint requests: Robert A. Schwartz, MD, MPH, Professor & Head, Dermatology, New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103.

Newark, New Jersey


Acanthosis nigricans is a velvety thickening of the epidermis that primarily affects the axillae, posterior neck fold, flexor skin surfaces, and umbilicus, and infrequently is diffuse with involvement of the mucosal surfaces. It is increasingly seen in children and adolescents who are obese, and can serve as a cutaneous marker of insulin resistance and malignancy. Although malignancy-associated acanthosis nigricans is rare in the pediatric population, one need be concerned about its association with certain pediatric syndromes. More importantly, insulin resistance itself can also represent a threat to life. We review this important disorder.

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 Funding sources: None.
Conflicts of interest: None declared.

© 2007  American Academy of Dermatology, Inc.@@#104156@@