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Joint Bone Spine
Volume 73, n° 3
pages 311-313 (mai 2006)
Doi : 10.1016/j.jbspin.2004.12.015
Received : 11 October 2004 ;  accepted : 3 December 2004
Disseminated Kikuchi-Fujimoto disease: a case report

Sondes Mseddi a, , Salwa Makni b, Moez Elloumi a, Tahia Boudawara b, Mounir Frikha a, Taoufik Souissi a
a Hematology Department, Hédi Chaker Hospital 3029 Sfax, Tunisia 
b Pathology Laboratory, Habib Bourguiba Hospital 3029 Sfax, Tunisia 

Corresponding author. Tel./fax: +216 74 240 549.

Subacute necrotizing lymphadenitis or Kikuchi-Fujimoto disease is a benign pathological entity diagnosed chiefly in young adults. We report a case in a 20-year-old woman who presented with swollen lymph nodes and a fever. Disseminated lymphadenopathy with nodes measuring up to 6 cm in diameter was found upon physical examination. The erythrocyte sedimentation rate was elevated to 40 mm/h and the lactic dehydrogenase level to 593 IU/l. Findings were negative from serological tests for rubella, hepatitis B, hepatitis C, HIV, and toxoplasmosis, as well as from tests for tuberculosis. A biopsy of a cervical lymph node showed nonsuppurative necrosis, karyorrhexis, and a marked histiocytic reaction consistent with Kikuchi-Fujimoto disease. No treatment was given, and a full recovery was achieved within 3 months. In this patient, the disseminated lymphadenopathy and constitutional symptoms strongly suggested a hematological malignancy and more specifically a lymphoproliferative disease.

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Keywords : Kikuchi-Fujimoto disease, Necrotizing lymphadenitis, Disseminated form

© 2006  Elsevier SAS. All Rights Reserved.