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Joint Bone Spine
Volume 73, n° 3
pages 321-324 (mai 2006)
Doi : 10.1016/j.jbspin.2005.10.018
Received : 14 Mars 2005 ;  accepted : 4 October 2005
A rare European case of Madura Foot due to actinomycetes

Luigi De Palma a, , Mario Marinelli a, Matteo Pavan a, Ester Manso b, Renzo Ranaldi c
a Cattedra di Ortopedia e Traumatologia, Università Politecnica delle Marche, Ancona, Ospedali Riuniti Umberto 1°-Lancisi-Salesi, Via Conca, 60100 Ancona, Italy 
b Istituto di Microbiologia, Università Politecnica delle Marche, Ancona, Italy 
c Istituto di Anatomia Patologica, Università Politecnica delle Marche, Ancona, Italy 

Corresponding author. Tel.: ++39-071-5963349, fax: ++39-071-5963349.

We present a case of mycetoma by Actinomadura spp. on the foot of an Albanian young man arrived to our observation approximately 5 years after the first clinical manifestations (hard tumefaction, slightly painful upon weight-bearing and palpation and cutaneous fistulas that discharged an abundant granulomatous secretion). Direct microscopic analysis and culture of the white-yellowish grains included Gram staining, which showed extensively branched Gram-positive hyphae less than 1 mm in diameter, allowing to make a diagnosis of Actinomycetoma. Since Actinomycetoma is sensitive to drug treatment, the patient was given trimethoprim-sulfamethoxazole and amikacin twice daily for 45 days. After six months of chemotherapy, the patient's general condition improved, the swelling is slightly diminished and grain extrusion has ceased. The patient has been able to resume ambulation with normal footwear. Given the absence of liver and kidney functional alterations, the patient is scheduled to continue pharmacological treatment with trimethoprim-sulfamethoxazole.

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Keywords : Actinomycetoma, mycetoma, fungal infection, maduromycosis, fungal mycetoma

© 2006  Elsevier SAS. All Rights Reserved.