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Journal of the American Academy of Dermatology
Volume 48, n° 2S
pages 1-4 (février 2003)
Doi : 10.1067/mjd.2003.112
Intravascular lymphomatosis of the skin as a manifestation of recurrent B-cell lymphoma

Kenji Asagoe, MDa, Wataru Fujimoto, MDa, Tadashi Yoshino, MDb, Tomohiko Mannami, MDb, Yixuan Liu, MDb, Hiroko Kanzaki, MDa, Jirô Arata, MDa
Okayama, Japan 
From the Department of Dermatologya and Second Department of Pathology,b Okayama University Medical School 


Intravascular lymphomatosis (IVL) is a rare type of lymphoma with a poor prognosis. Its distinctive clinical and histopathologic features are generated by the proliferation of neoplastic mononuclear cells within blood vessels. We describe a patient with IVL of the skin as a manifestation of a recurrent diffuse large B-cell lymphoma of ureteral origin. Lymphoma cells were located both within the vessels and the parenchyma in an early cutaneous lesion. After recurrence in the skin, lymphoma cells gradually located only in the vascular lumina. This transition suggests that cells localized within the vessels were selected as a consequence of chemotherapy. Immunohistochemical examination revealed that the expression of surface adhesion molecules of lymphoma cells did not significantly change. The results of polymerase chain reaction revealed that the ureteral and cutaneous tumors were identical in clonality. Our findings suggest that conventional diffuse large B-cell lymphoma can change into IVL. (J Am Acad Dermatol 2003;48:S1-4.)

The full text of this article is available in PDF format.

 This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology.
 Reprint requests: Dr Kenji Asagoe, Department of Dermatology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. E-mail:
 0190-9622/2003/$30.00 + 0

© 2003  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@