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Journal of the American Academy of Dermatology
Volume 48, n° 2S
pages 28-30 (février 2003)
Doi : 10.1067/mjd.2003.123
CD30 (Ki-1)-positive large-cell cutaneous T-cell lymphoma with secondary xanthomatous changes after radiation therapy

Han Gil Chung a, Yae Lee Chung a, Jin Moon Kang a, Woo Ick Yang b, Chang Ok Suh c, Jee Sook Hahn d, Min-Geol Leea a,b,c,d
Seoul, Korea 
From the Departments of Dermatology,a Pathology,b Radiation Oncology,c and Internal Medicine,d Yonsei University College of Medicine 


A 72-year-old woman with a large mass on her forehead was found to have primary cutaneous CD30-positive large T-cell lymphoma and was treated with radiation therapy. Five weeks after the completion of radiation therapy, a large, yellow plaque developed on the forehead. Histopathologic examination showed numerous xanthoma-like cells with clear and foamy cytoplasm that infiltrated the upper and mid dermis with no residual lymphoma. To our knowledge, this is the first report of xanthomatous change after radiation therapy for primary cutaneous CD30-positive large cell lymphoma. We believe that the xanthomatous change after radiation therapy probably was caused by lysis of radiosensitive lymphoma cells and histiocytic scavenging of lipid-membrane debris. (J Am Acad Dermatol 2003;48:S28-30.)

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 This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology.
 Reprint requests: Min-Geol Lee, MD, Department of Dermatology, Yonsei University College of Medicine, CPO Box 8044 Seoul, 120-752, Korea. E-mail:
 0190-9622/2003/$30.00 + 0

© 2003  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@