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Journal of the American Academy of Dermatology
Volume 44, n° 2P2
pages 348-350 (février 2001)
Doi : 10.1067/mjd.2001.103034
Childhood bullous pemphigoid developed after the first vaccination

Can Baykal, Gökhan Okan, Rifkiye Sarica
Department of Dermatology, Istanbul Medical Faculty, Istanbul University. Istanbul, Turkey 


Bullous pemphigoid (BP) typically affects the elderly. There are at least 40 reported cases of BP in childhood, 10 reported cases at 1 year of age or younger. The antigen of this autoimmune disease is localized to the hemidesmosome. Neoplasia, recurrent trauma, some systemic diseases, and psoriasis were previously reported as possible triggering factors of bullous pemphigoid in some cases. In the last 5 years, 10 adult and 2 infantile BP cases with a close relation of vaccination have been reported. Anti-influenza vaccine, tetanus toxoid booster, and tetracoq vaccine were the possible causes of these cases. We report herein a 3.5-month-old BP case in whom the lesions developed 24 hours after the first tetracoq vaccine. We suggest that vaccination may be the triggering factor of BP of any age by stimulating the immune system with an unexplained mechanism. (J Am Acad Dermatol 2001;44:348-50.)

The full text of this article is available in PDF format.

 This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology.
 Reprint requests: Dr Can Baykal, IÜ Istanbul Tip Fakültesi, Dermatoloji Ana Bilim Dali, 34390 Çapa-Istanbul Turkey. E-mail:
 J Am Acad Dermatol 2001;44:391-4

© 2001  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@