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Journal of the American Academy of Dermatology
Volume 38, n° 5S
pages 844-848 (mai 1998)
Doi : 10.1016/S0190-9622(98)70472-4
Bullous systemic lupus erythematosus: Detection of antibodies against noncollagenous domain of type VII collagen

Shigeho Shirahama, MDa, Fukumi Furukawa, MDa, Hiroaki Yagi, MDa, Toshihiro Tanaka, MDb, Takashi Hashimoto, MDc, Masahiro Takigawa, MDa
Hamamatsu, Kyoto, and Tokyo Japan 
From the Department of Dermatology, Hamamatsu University School of Medicinea ; Department of Dermatology, Faculty of Medicine, Kyoto University,b ; and Department of Dermatology, Kurume University School of Medicine, Tokyo. c 


A 9-year-old girl with systemic lupus erythematosus developed bullous eruption. Histopathologic examination showed subepidermal blistering and immunoglobulins (IgG, IgM, IgA) and complement components (C1q, C3) deposited linearly at the basement membrane zone. IgG in this patient’s serum bound to the dermal side of 1 mol/L sodium chloride-split normal human skin, and a 290 kd protein was identified in the dermal extract. The patient’s serum recognized various epitopes on the noncollagenous domain as demonstrated by the use of fusion proteins of type VII collagen. Resolution of the bullous eruption occurred after treatment with dapsone. (J Am Acad Dermatol 1998;38:844-8.)

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 This article is made possible through an educational grant from the Ortho Dermatological.
 Supported in part by a grant from Japanese Ministry of Health and Welfare.
 Reprint requests: Shigeho Shirahama, Department of Dermatology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu-shi, Shizuoka, Japan 431-31.
 0190-9622/98/$5.00 + 0 16/4/84852

© 1998  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@