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Journal of the American Academy of Dermatology
Volume 39, n° 3
pages 428-433 (septembre 1998)
Doi : 10.1016/S0190-9622(98)70319-6
accepted : 6 May 1998
Risk of melanoma in medium-sized congenital melanocytic nevi: A follow-up study

Sedef Sahin, MD, Ludmila Levin, BA, Alfred W. Kopf, MD, Babar K. Rao, MD, Marc Triola, BA, Karen Koenig, PhD, Carol Huang, MD, Robert Bart, MD
Ronald O. Perelman Department of Dermatology and the Department of Environmental Medicine, New York University School of Medicine; the Oncology Section of the Charles C. Harris Skin and Cancer Pavilion, New York University Medical Center; the New York University Melanoma Cooperative Group; and the State University of New York at Stony Brook School of Medicine. New York, New York 


Background: The risk of the occurrence of malignant melanoma (MM) in medium-sized (1.5 to 19.9 cm in diameter) congenital melanocytic nevi (CMN) is the subject of controversy. Universally accepted recommendations regarding the management of such lesions have not been made. Objective: Our purpose was to assess the risk of MM arising in medium-sized CMN. Methods: The study included 230 medium-sized CMN in 227 patients, first seen in a private dermatology practice from 1955 to 1996, who were followed up for MM arising within their CMNs. Criteria for entry into the study included (1) a clinically diagnosed medium-sized CMN, (2) minimum follow-up period of 1 year, and (3) a photograph of the lesion in the patient’s medical record. Results: No MM occurred in a medium-sized CMN during an average follow-up of 6.7 years (median, 5.8 years) to an average age of 25.5 years (median, 19.1 years). Conclusion: The results of this short-term follow-up study do not support the view that there is a clinically significantly increased risk for MM arising in banal-appearingmedium-sized CMN or that prophylactic excision of all such lesions is mandatory. Life-long medical observation seems a reasonable alternative for many medium-sized CMN. (J Am Acad Dermatol 1998;39:428-33.)

The full text of this article is available in PDF format.

 Supported by the Joseph H. Hazen Foundation; the Ronald O. Perelman Department of Dermatology, New York University School of Medicine; the Niarchos Fund of the Skin Cancer Foundation; the Kaplan Cancer Center (Cancer Center Support Core Grant No 5P30 CA-16087); the Mary and Emanuel Rosenfeld Foundation; Nina W. Werblow Charitable Trust; National Institutes of Health/National Cancer Institute grant 2R44CA/AR60229-02; and by Scientific and Technical Research Council of Turkey (TUBITAK).
 Reprint requests: Alfred W. Kopf, MD, The Ronald O. Perelman Department of Dermatology, Oncology Section, Skin and Cancer Unit, New York University Medical Center, 550 First Ave, New York, NY 10016.
 0190-9622/98/$5.00 + 0  16/1/91565

© 1998  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@