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Journal of the American Academy of Dermatology
Volume 39, n° 3
pages 439-442 (septembre 1998)
Doi : 10.1016/S0190-9622(98)70321-4
accepted : 6 May 1998
Diffuse plane xanthoma: Clinicopathologic study of 8 cases

Joaquim Marcoval, MDa, Abelardo Moreno, MDb, Xavier Bordas, MDa, Fernando Gallardo, MDa, Jordi Peyrí, MDa
Barcelona, Spain 
From the Departments of Dermatology,a and Pathology,b Hospital “Prínceps D’Espanya,” Barcelona 


Background: Diffuse plane xanthoma (DPX) usually has been described in association with a reticuloendothelial disease. However, the incidence of an underlying disease and its relation to clinical and histopathologic features have not been previously described. Objective: We describe the clinicopathologic features of a series of patients with DPX. Methods: Eight patients with DPX were diagnosed and studied between 1987 and 1996. Results: Three of the 8 patients had a reticuloendothelial disease (benign monoclonal gammopathy in 2 and chronic myelomonocytic leukemia in 1). These 3 patients had larger cutaneous lesions and involvement of trunk and extremities. Histologic examination showed only foamy macrophages in 2 of the 8 patients. The remainder exhibited macrophages, foamy histiocytes, lymphocytes, and Touton cells. Conclusion: The incidence of underlying disease associated with DPX seems to be lower than expected. However, patients with DPX should be observed for the potential occurrence of an associated condition. (J Am Acad Dermatol 1998;39:439-42.)

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 Reprint requests: Joaquim Marcoval, MD, Department of Dermatology, Hospital de Bellivitge, c/Feixa Llarga s/n, Hospitalet de Llobregat, 08907 Barcelona, Spain.
 0190-9622/98/$5.00 + 0  16/1/91556

© 1998  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@