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Journal of the American Academy of Dermatology
Volume 38, n° 6
pages 950-954 (juin 1998)
Doi : 10.1016/S0190-9622(98)70158-6
accepted : 7 Mars 1998
Analysis of vascularity of human neurofibromas

Jack L. Arbiser, MD, PhD a, b, Evelyn Flynn b, Raymond L. Barnhill, MD c
a Department of Dermatology, Harvard Medical School Boston, Massachusetts 
b Department of Surgery, Childrens Hospital Boston, Massachusetts 
c Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School. Boston, Massachusetts 


Background: A common misperception is that the vascularity of a tumor can be determined by its gross appearance. Neurofibromas are grossly white in appearance. The degree of vascularity of neurofibromas has not been determined. Objective: The purpose of this study was to determine the extent of neovascularization of neurofibromas. Methods: Neurofibromas from patients with neurofibromatosis-1 or spontaneous neurofibromas were stained with antibodies against von Willebrand factor (factor VIII–related antigen) and vascular endothelial growth factor (VEGF). Results: Neurofibromas, both spontaneous and congenital, exhibit a high degree of vascularity. In addition, perivascular cells in neurofibromas stain with antibodies to VEGF, an angiogenic factor. Conclusion: Neurofibromas, despite their gross appearance, are highly vascular. Their vascularity may be mediated, in part, through the angiogenic factor VEGF. (J Am Acad Dermatol 1998;39:950-4.)

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 Supported in part by a Howard Hughes Postdoctoral Fellowship (to J. L. A.) and a grant from the Society for Pediatric Dermatology (to J. L. A.), the KAO Corporation Thomas B. Fitzpatrick Research Award (to J. L. A.), National Institutes of Health grant RO3AR44947 (to J. L. A.), and a Dermatology Foundation Clinical Career Development Award (to J. L. A.).
 Reprint requests: Jack L. Arbiser, MD, PhD, Emory University School of Medicine, Dept. of Dermatology, WMB 5th Floor, 1639 Pierce Dr., Atlanta, GA 30322.
 0190-9622/98/$5.00 + 0   16/1/90113

© 1998  American Academy of Dermatology, Inc. Published by Elsevier Masson SAS@@#104157@@