Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: A retrospective cohort study from Taiwan - 09/02/13
Abstract |
Background |
The development of autoimmune sequelae is one of the characteristic features of drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome; however, the incidence of sequelae and prognosis of patients with DRESS are unknown.
Objective |
We sought to investigate the incidence of sequelae, including less well-known sequelae, and long-term prognosis in patients with DRESS/drug-induced hypersensitivity syndrome.
Methods |
A retrospective cohort study was conducted at a medical center in northern Taiwan using a DRESS/drug-induced hypersensitivity syndrome database. Patients who were followed up for at least 1 year were included in the study.
Results |
Nine patients died before interview, whereas 43 patients completed a specially designed questionnaire. The overall cumulative incidence of long-term sequelae was 11.5% (6 of 52 patients). Four patients developed autoimmune diseases, specifically Graves disease (n = 2), type 1 diabetes mellitus (n = 1), and autoimmune hemolytic anemia (n = 1). Alopecia areata was also noted in 1 of the 2 patients with Graves disease. The other 2 patients developed renal failure after visceral involvement and required lifetime hemodialysis.
Limitations |
Our study included a small number of patients. Further, viral studies were not performed.
Conclusion |
The sequelae of DRESS can be divided into 2 major types that appear to occur in different age groups: young patients tend to develop autoimmune diseases, whereas elderly patients are more vulnerable to end-organ failure.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune diseases, drug-induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms, sequelae
Abbreviations used : AIHA, AITD, DM, DRESS, SLE, TSH
Plan
Drs Chen and Chang contributed equally to this work. |
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Funding sources: None. |
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Conflicts of interest: None declared. |
Vol 68 - N° 3
P. 459-465 - mars 2013 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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