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Journal of the American Academy of Dermatology
Volume 68, n° 3
pages 489-492 (mars 2013)
Doi : 10.1016/j.jaad.2012.08.021
accepted : 14 August 2012
Reviews

Remission of psoriasis after allogeneic, but not autologous, hematopoietic stem-cell transplantation
 

Benjamin H. Kaffenberger, MD a, , Henry K. Wong, MD, PhD a, Wael Jarjour, MD b, Leslie A. Andritsos, MD c
a Dermatology, Ohio State University College of Medicine, Columbus, Ohio 
b Rheumatology, Ohio State University College of Medicine, Columbus, Ohio 
c Hematology and Blood and Marrow Transplantation, Ohio State University College of Medicine, Columbus, Ohio 

Reprint requests: Benjamin H. Kaffenberger, MD, Dermatology, Ohio State University, 540 Officenter Place, Gahanna, OH 43216.
Abstract

Hematopoietic stem-cell transplantation (HSCT) has emerged as an effective immunotherapy for several severe autoimmune diseases. A comprehensive search of the existing literature was performed for patients with psoriasis and HSCT. Nineteen patients have been reported to have psoriasis resolution after allogeneic or autologous HSCT. In the allogeneic setting, 10 of 13 were noted to have durable remission of their psoriasis with a mean follow-up of 49 months. Two cases that did reoccur were only transient. Six patients underwent autologous transplantation. Of these, 5 of 6 developed a recurrence of their psoriasis within 2 years. Based on a limited number of patients, psoriasis is likely to remit after allogeneic HSCT, but it is likely to recur after autologous HSCT.

The full text of this article is available in PDF format.

Key words : allogeneic, autologous, bone-marrow transplant, cancer, hematopoietic stem-cell transplantation, immunotherapy, medical dermatology, psoriasis vulgaris



 Funding sources: None.
 Conflicts of interest: None declared.



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