Segmental and nonsegmental childhood vitiligo has distinct clinical characteristics: A prospective observational study - 24/04/13
, Sophie Bezio a, Emmanuel Mahe, MD b, Christine Bodemer, MD, PhD c, Catherine Eschard, MD d, Valérie Viseux, MD e, Christine Labreze, MD f, Patrice Plantin, MD g, Sebastien Barbarot, MD h, Pierre Vabres, MD i, Ludovic Martin, MD j, Carle Paul, MD, PhD a, Jean-Philippe Lacour, MD kGroupe de Recherche Clinique en Dermatologie Pédiatrique (GRCDP)
Reprint requests: Juliette Mazereeuw-Hautier, MD, PhD, Purpan Hospital, Dermatology, 1, Place de Dr Baylac, Toulouse 31059, France.Abstract |
Background |
Vitiligo often starts in childhood. It is traditionally divided into segmental vitiligo and nonsegmental vitiligo. There are limited data regarding the clinical characteristics of both forms and no comparative study has been performed.
Objective |
To compare the clinical features of nonsegmental and segmental vitiligo in children.
Patients and Methods |
We performed a prospective observational study. Consecutive children with vitiligo seen between October 2005 and December 2007 in the 11 French Departments of Pediatric Dermatology were included. A standardized evaluation was completed after total body clinical examination. A second examination was performed 1 year after inclusion. The clinical characteristics of segmental vitiligo and nonsegmental vitiligo were compared.
Results |
A total of 114 children with vitiligo were included. Compared with segmental vitiligo, nonsegmental vitiligo was associated with a higher number of lesions (more than 5 patches in 65.17% vs 20% of patients, P < .0001) and a larger body surface area of involvement (9.8% ± 2.51% vs 3.48% ± 1.6%, P ± .01). A higher incidence of the Koebner phenomenon (47.19% vs 24%, P = .03), and more frequent progression of the disease (23.29% vs 5.56%, P = .043) were found in nonsegmental vitiligo. Hyperpigmented rims surrounding patches of vitiligo were only seen in nonsegmental vitiligo (8.99% vs 0% (P = .007). Sixty-four children (56%) had laboratory investigations performed; thyroid abnormalities were found only in nonsegmental vitiligo (11.23% vs 0%, P = .0001).
Limitations |
Not all patients underwent laboratory investigations.
Conclusions |
Segmental and nonsegmental types of vitiligo have distinguishing clinical characteristics.
Le texte complet de cet article est disponible en PDF.Key words : childhood, vitiligo, segmental or nonsegmental
Abbreviations used : NSV, SV
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 62 - N° 6
P. 945-949 - juin 2010 Retour au numéro
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