High numbers of DC-SIGN+ dendritic cells in lesional skin of cutaneous T-cell lymphoma - 24/04/13
Abstract |
Background |
The role of dendritic cells (DCs) in disease progression of primary cutaneous T-cell lymphoma (CTCL) is not well understood. With their unique ability to induce primary immune responses as well as immunotolerance, DCs play a critical role in mediation of anti-tumor immune responses. Tumor-infiltrating DCs have been determined to represent important prognostic factors in a variety of human tumors.
Objective |
To date, only circulating DC populations have been investigated in CTCL. Therefore we analyzed the expression and tissue distribution of different DC subset markers in lesional and nonlesional skin of patients with CTCL.
Methods |
Twelve patients with mycosis fungoides or Sézary syndrome were included in the study. Tissue samples were obtained from lesional and nonlesional skin as a control. Immunohistochemistry was performed with different DC subset and regulatory T-cell markers and assessed using a digital image analysis system. Tissue distribution of DCs in relation to the tumor was analyzed by double immunofluorescence.
Results |
We found a significant infiltration of CTCL lesions by immature CD209/DC-SIGN+ DCs with close contact to tumor cells. Matured and activated DCs were only rarely detected in lesions of CTCL.
Limitations |
The sample size was small.
Conclusions |
The preponderance of immature CD209/DC-DIGN+ DCs in contact with regulatory T cells in lesions of CTCL points to an important role of this subset in the host’s immune reaction to the malignant T cells. Since these immature DCs are known to induce immunotolerance, they might play a role in the mediation of immune escape of the proliferating clone.
Le texte complet de cet article est disponible en PDF.Key words : CTCL, cutaneous T-cell lymphoma, DC-SIGN/CD209, dendritic cell, dendritic cell subsets, mycosis fungoides, Sézary syndrome, tumor immunology
Abbreviations used : CD, CTCL, DC, IL, MUC1, T reg
Plan
Dr Hassan is currently with the Department of Dermatology, Cairo University, 11559-Cairo, Egypt. |
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Supported by the Bernische Krebsliga, Bern. |
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Conflicts of interest: None declared. |
Vol 62 - N° 6
P. 995-1004 - juin 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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