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Journal of the American Academy of Dermatology
Volume 63, n° 2
pages 266-273 (août 2010)
Doi : 10.1016/j.jaad.2009.08.056
accepted : 14 August 2009
Original Articles

Long-term follow-up study of clear cell papulosis

Fang-Wen Tseng, MD a, Tseng-Tong Kuo, MD, PhD b, c, Pei-Hsuan Lu, MD a, c, Heng-Leong Chan, MD d, Ming-Jing Chan, MD a, c, Rosaline Chung-Yee Hui, MD, PhD a, c,
a Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan 
b Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan 
c Chang Gung University College of Medicine, Taipei, Taiwan 
d Department of Dermatology, Sutein Clinic, Taipei, Taiwan 

Reprint requests: Rosaline Chung-Yee Hui, MD, PhD, Department of Dermatology, Chang Gung Memorial Hospital, No. 199, Tung-Hwa North Road, Taipei, Taiwan.

Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown.


The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome.


Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed.


With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density.


Retrospective nature of the study is a limitation.


No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.

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Key words : clear cell papulosis, clear cells of Toker, extramammary Paget disease, long-term follow-up, milk line

Abbreviations used : CCP, CEA, EMA, EMPD, MPD, PAS

 Funding sources: None.
 Conflicts of interest: None declared.

© 2009  American Academy of Dermatology, Inc.@@#104156@@