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Joint Bone Spine
Volume 80, n° 6
pages 586-591 (décembre 2013)
Doi : 10.1016/j.jbspin.2013.04.002
accepted : 28 February 2013
Osteoclasts in RA: Diverse origins and functions
 

Benoit Le Goff a, , b, c, d , Jean-Marie Berthelot a, c, Yves Maugars a, b, c, d, Dominique Heymann a, b, c, d, e
a Service de rhumatologie, Hôtel-Dieu, 1, place Alexis-Ricordeau, 44093 Nantes cedex 1, France 
b LUNAM université, 44000 Nantes, France 
c Inserm, UMR957, physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitives, 44035 Nantes, France 
d Université de Nantes, Nantes atlantique universités, 44035 Nantes, France 
e Équipe LIGUE 2012, France 

Corresponding author. Tel.: +33 2 40 08 48 48; fax: +33 2 40 08 48 30.
Abstract

Osteoclasts were recognized in the late 1990s as the cells responsible for generalized and focal bone loss in rheumatoid arthritis (RA). Concepts about osteoclast biology have changed radically based on recent evidence of considerable diversity in both the origins and the functions of osteoclasts. In addition, the role for osteoclasts is not confined to bone resorption but may also include active contributions to inflammatory and autoimmune responses. Thus, in RA, osteoclast progenitors may arise from both circulating cells and cells developed within the rheumatoid synovium or subchondral bone. Within the inflamed synovium, osteoclasts are activated by factors such as cytokines, immune complexes, or activators of the toll-like receptors, which are not found in healthy bone tissue. Finally, recent data suggest that osteoclasts may be capable of antigen presentation to T cells via major histocompatibility complex class I and class II molecules. Confirmation of this suggestion by future studies would indicate that osteoclasts might be involved not only in bone resorption, but also in autoimmune responses and antigen presentation. These data highlight the considerable complexity of interactions between bone tissue and the immune system. Research into these interactions may identify new targets for treatments against the bone abnormalities associated with chronic inflammatory disease.

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Keywords : Osteoclasts, Rheumatoid arthritis, T lymphocyte, B lymphocyte, Immune complexes, Toll-like receptors




© 2013  Société française de rhumatologie@@#104156@@